| Description | L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM). |
| In vitro | L-2,4-Diaminobutyric acid(DABA) was a non-linear, non-competitive inhibitor of GABA transaminase activity. The DABA-induced elevation of GABA levels paralleled the inhibition of GABA transaminase activity. DABA was a more effective inhibitor of GABA transaminase in vivo than in vitro, and this inhibition probably produced the elevation of GABA levels. The neurotoxicity of DABA appears to produce a use in GABA replacement therapy[1]. |
| Synonyms | L-2,4-Diaminobutyric acid, L-2,4-二氨基丁酸氢溴酸盐, L-DAB HBR |
| molecular weight | 118.13 |
| Molecular formula | C4H10N2O2 |
| CAS | 1758-80-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble H2O: Insoluble |
| References | 1. Beart P M , Bilal K . l-2,4-Diaminobutyric acid and the GABA system[J]. Neuroscience Letters, 1977, 5(3-4):193-198. 2. Ronquist G , Hugosson R , Westermark B . Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo.[J]. Journal of Cancer Research & Clinical Oncology, 1980, 96(3):259-68. |