| Description | Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). |
| In vitro | Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2. Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively. |
| Target activity | β-glucuronidase:2.07 μM (IC50), CES2A (human):3.05 μM (IC50) |
| Synonyms | 苦参醇X |
| molecular weight | 440.49 |
| Molecular formula | C25H28O7 |
| CAS | 254886-77-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lavandulyl flavonoids with sodium-dependent glucose cotransporter 2 inhibitory activity from Sophora flavescensJournal of Huazhong Normal University, 2014 , 48 (4) :520-4. |