| Description | Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. |
| In vivo | Kavain treatment in RAW264.7 cells deactivated MyD88 and Akt, inhibited LITAF, and reduced the production of TNF-α, IL-27, and MIG in response to LPS. Similarly, it had a significant in vivo anti-inflammatory effect on wild-type (WT) mice that developed Collagen Antibody Induced Arthritis (CAIA). |
| molecular weight | 230.26 |
| Molecular formula | C14H14O3 |
| CAS | 3155-48-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (195.43 mM) |
| References | 1. Tang X , Amar S . Kavain Involvement in LPS-Induced Signaling Pathways[J]. Journal of Cellular Biochemistry, 2016:n/a-n/a. |