| Description | Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part, by the opening of ATP-sensitive potassium channels. Kaurenoic acid exhibits an analgesic effect in a consistent manner and that its mechanisms involve the inhibition of cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. Kaurenoic acid derivatives have an antimicrobial activity of substituted on carbon-15 at concentrations greater than or equal to 250 μg/ml. Kaurenoic acid has inhibitory effects on the LPS-induced inflammatory response in RAW264.7 macrophages. |
| Synonyms | Kauren-19-Oic Acid, 异贝壳杉烯酸, kaurenoate, kaur-16-en-18-oic acid |
| molecular weight | 302.45 |
| Molecular formula | C20H30O2 |
| CAS | 6730-83-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Chloroform: Soluble DMSO: 55 mg/mL(181.8 mM) |
| References | 1. Okoye T C, et al. Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis.[J]. Pharmacology Biochemistry & Behavior, 2013, 109(8):38-43. 2. Choi R J, et al. Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages[J]. Phytomedicine, 2011, 18(8):677-682. 3. Fernandes V C, et al. The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction[J]. Genetics & Molecular Research, 2013, 12(2):12005-12011. 4. Jeong S I, et al. Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans.[J]. 2016, 2013:160592. |