| Description | Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside bacteriocidal antibiotic. |
| In vitro | 在MRS培养基中，Kanamycin sulfate 浓度超过0.0025%对B. bifidum生长有显著抑制作用，但在12小时或24小时的培养期内对其他四种益生菌无影响。Kanamycin sulfate 用于B.bifidum选择性计数的合适选择性浓度为0.005%[3]。 |
| In vivo | 通过大鼠DCN受卡那霉素（500 mg/kg/天）诱导的神经元损伤是可逆的，且在卡那霉素对DCN神经毒性过程中，通过JNK1介导的Bcl-2通路磷酸化作用，促进了自噬的上调。卡那霉素给药后第1天，血清BUN和Cr水平均有所上升。与对照组相比，卡那霉素给药后1天、7天和14天，表达LC3的神经元数量增加。卡那霉素治疗以时间依赖的方式增加自噬[1]。Kanamycin sulfate（5 mg/kg）和氨苄西林钠（10 mg/kg）分别通过肌肉内（i.m.）注射给五匹小型母马，注射后大约2.5小时后炎症滑液中的氨苄西林浓度超过5 mg/mL，而Kanamycin sulfate 浓度在7小时内超过2 mg/mL[2]。 |
| Synonyms | 硫酸卡那霉素, Kanamycin monosulfate, Kanamycin A monosulfate, Ophtalmokalixan |
| molecular weight | 582.58 |
| Molecular formula | C18H38N4O15S |
| CAS | 25389-94-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 50 mg/mL (85.82 mM) DMSO: Insoluble |
| References | 1. Fan GR, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. 2. Mohamed el SW, et al. Tongue actinomycetoma due to Actinomadura madurae: a rare clinical presentation. J Oral Maxillofac Surg. 2012 Nov;70(11):e622-4. 3. Guo WS, et al. Effect of Kanamycin Sulfate and Gentamicin on Growth of Probiotics. Advanced Materials Research,2011, 366, 490-493. 4. Firth EC, et al. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J Vet Pharmacol Ther. 1988 Mar;11(1):56-62. |