| Description | Kaempferol 7-O-rhamnoside is a natural product from Maytenus hookeri. |
| In vitro | The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), Kaempferol 7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11). The experiments of ultra-filtration combined with liquid chromatography-mass spectrometry (UF-LC-MS) guided quercetin and kaempferol as the key factors for 50% EE showing highly inhibitory activity on α±-glucosidase. Quercetin and kaempferol inhibited yeast α±-glucosidase in a mixed-type manner with IC50 of 66.8 and 109μg/mL, respectively[1] |
| Synonyms | Kaempferol 7-O-rhamnoside, 山奈酚-7-O-鼠李糖苷 |
| molecular weight | 432.38 |
| Molecular formula | C21H20O10 |
| CAS | 20196-89-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on α±-glucosidase activity.International Journal of Biological Macromolecules, 2017,98:829-36. |