| Description | Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin. |
| In vitro | Jasplakinolide（1 mM；60分钟）能诱导单独固定的弓形虫速殖子形成含肌动蛋白的顶端突起。Jasplakinolide对PC3前列腺癌细胞的抗增殖作用具有35 nM的IC50 值。[1] 在有丝分裂期间处理，Jasplakinolide （10 μM；2小时）会产生双核细胞。Jasplakinolide还能促进弓形虫速殖子形成含F-actin的顶端突起。[2] |
| Synonyms | Jaspamide, NSC-613009 |
| molecular weight | 709.67 |
| Molecular formula | C36H45BrN4O6 |
| CAS | 102396-24-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71. 2. Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87. |