| Description | Isovalerylshikonin is a natural product from Onosma heterophylla and Arnebia euchroma. |
| In vitro | Isovalerylshikonin 对抗药物耐药性的金黄色葡萄球菌 (Staphylococcus aureus) RN4220 显示出了较弱的抗菌活性，最小抑菌浓度 (MIC) 为 16 mg/L[1]。 |
| In vivo | 采用腹膜炎/败血症模型评估了IVS与STM的体内协同作用。IVS与STM协同降低了小鼠腹膜、脾脏和肝脏中的细菌计数，并在7天内提高了小鼠的存活率。IVS的急性毒性得到了测试，其单次暴露的LD50为2.584 g/kg。总体而言，具有低毒性抗性改变剂特性的异戊酰紫草素，展现了针对耐药金黄色葡萄球菌(S. aureus)的体内外协同抗菌活性。这些效果是通过抑制msrA mRNA表达和细菌外排[1]来介导的。 |
| Target activity | S. aureus:16 mg/L(MIC) |
| molecular weight | 372.41 |
| Molecular formula | C21H24O6 |
| CAS | 76549-35-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018. |