| Description | Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver. |
| In vitro | 经口单次给予Indican，剂量为20、40 mg/kg，通过其主要代谢产物吲哚磺酸（IS）[3]抑制包括OAT 1、OAT 3和MRP 4在内的多种阴离子转运蛋白，从而增加了MTX和MRT的系统暴露度。 |
| Synonyms | NSC-87517, 3-Indoxyl-beta-D-glucopyranoside, 3-吲哚基-beta-D-吡喃葡萄糖苷, NSC 87517, NSC87517, Indoxyl-β-D-glucoside |
| molecular weight | 295.29 |
| Molecular formula | C14H17NO6 |
| CAS | 487-60-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 8 mg/mL (27.09 mM) DMSO: 88 mg/mL (298.01 mM) |
| References | 1. Kamiński T, Michałowska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review. 2. Wu CC, Hung SC, Kuo KL, Tarng DC. Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access. Toxins (Basel). 2017 Jan 7;9(1). pii: E25. 3. Gao H, Liu S. Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease. Life Sci. 2017 Sep 15;185:23-29. doi: 10.1016/j.lfs.2017.07.027. Epub 2017 Jul 25. Review. PubMed PMID: 28754616. 4. Gao H, Liu S. Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease. Life Sci. 2017 Sep 15;185:23-29. |