| Description | Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds. |
| In vitro | Illudin M (0.01, 1和10 μM; 24-120小时; Panc-1, HT-29, HFs)在体外对肿瘤细胞(Panc-1 86%；HT-29 48%)以及HF(89%)显示出相当的诱导凋亡作用。[1] |
| molecular weight | 248.32 |
| Molecular formula | C15H20O3 |
| CAS | 1146-04-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble DMF: Soluble Methanol: Soluble Ethanol: Soluble |
| References | 1. Schobert R, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7. 2. Le P, et al. A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. |