| Description | Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator. |
| Target activity | PDE5:0.432 μM |
| Synonyms | 淫羊藿苷, Ieariline, 淫羊藿甙 |
| molecular weight | 676.66 |
| Molecular formula | C33H40O15 |
| CAS | 489-32-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (88.67 mM) |
| References | 1. Song YX, et al. Chin J Integr Med. 2015 Nov 20. 2. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 3. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 4. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2021, 19(1): 1-14. |