| Description | Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane. |
| In vitro | Iberin以剂量和时间依赖的方式抑制神经母细胞瘤细胞的增长，并抑制细胞周期依赖性激酶Cdk2、Cdk4和Cdk6蛋白的表达。Iberin增加细胞的凋亡死亡，并激活caspase-9、caspase-3和PARP[2]。 |
| In vivo | Iberin在多种大鼠组织中提高了第二阶段解毒酶quinone reductase和GST的组织水平[5]。 |
| Target activity | Cell survival:2.3 μM |
| Synonyms | NSC 321801 |
| molecular weight | 163.26 |
| Molecular formula | C5H9NOS2 |
| CAS | 505-44-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 9.0 mg/mL (55.1 mM), Sonication is recommended. DMSO: 279.0 mg/mL (1708.9 mM） |
| References | 1. Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3375-86. 2. Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. 3. Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103(2):247-51. 4. Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. 5. Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7):1867-71. |