| Description | Hypoxanthine (Purin-6-ol), also known as purine-6-ol or Hyp. Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Under normal circumstances hypoxanthine is readily converted to uric acid.hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase. |
| In vitro | Hypoxanthine 是一种天然存在的嘌呤衍生物。作为核酸的组成部分，它偶尔在tRNA的反密码子中以其核苷形态--肌苷的形式出现。Hypoxanthine是一些特定细胞、细菌和寄生虫培养中不可或缺的添加物，用作底物和氮源。[1] |
| In vivo | A linear increase of plasma hypoxanthine with duration of hypoxemia is found in pigs, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. Moreover, there is a direct relationship between survival time and an increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62). All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine, thus, reflected the prognosis of acute hypoxia in contrast to base deficit[1]. |
| Synonyms | 次黄嘌呤, 6-羟基嘌呤, 6-Hydroxypurine, Purin-6-ol, Sarcine, Sarkin |
| molecular weight | 136.11 |
| Molecular formula | C5H4N4O |
| CAS | 68-94-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: Insoluble DMSO: 5 mg/mL (36.73 mM) |
| References | 1. Saugstad OD, Pediatr Res, 1988, 23(2), 143-150. 2. Skolnick P, et al. Life Sci, 1978, 23(14), 1473-1480. |