| Description | Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM). |
| Target activity | TRPV1:1.1 µM (EC50), TRPA1:69 µM (EC50) |
| Synonyms | 羟基-α-山椒素, Hydroxy-α-sanshool |
| molecular weight | 263.38 |
| Molecular formula | C16H25NO2 |
| CAS | 83883-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 37.5 mg/mL (142.38 mM) |
| References | 1. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409. |