| Description | hydrocotarnine is an inhibitor of Cbl. |
| In vivo | In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment[2]. |
| molecular weight | 221.25 |
| Molecular formula | C12H15NO3 |
| CAS | 550-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (248.59 mM) |
| References | 1. Lin H C , Chen Y J , Wei Y H , et al. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition[J]. International Journal of Molecular Sciences, 21(14). 2. Chung I C , Yuan S N , Ouyang C N , et al. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation[J]. Cell Death & Disease, 2018, 9(11). |