| Description | Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation. |
| In vitro | Hydrangenol通过降低透明质酸酶(HYAL)-1/-2的表达，提升了角蛋白、丝聚蛋白以及水通道蛋白-3 (AQP3)的表达和透明质酸(HA)的生成。与胶原蛋白构成的恢复一致，Pro-COL1A1的表达也因hydrangenol得到增加[1]。 |
| molecular weight | 256.25 |
| Molecular formula | C15H12O4 |
| CAS | 480-47-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (234.15 mM) |
| References | 1. Myung DB, et al. Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice. Nutrients. 2019 Oct 2;11(10):2354. 2. Gho Y, et al. Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression. Anim Cells Syst (Seoul). 2019 Feb 14;23(2):72-81. 3. Kim HJ, et al. Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway. Int Immunopharmacol. 2016 Jun;35:61-69. |