| Description | Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753 and is also a broad-spectrum antibiotic. holomycin promotes biofilm formation of S2753 through its alene-disthionyl group. Holomycin has antitumor activity and is involved in RNA synthesis. |
| Synonyms | N-Demethylthiolutin |
| molecular weight | 214.26 |
| Molecular formula | C7H6N2O2S2 |
| CAS | 488-04-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 11 mg/mL (51.34 mM) |
| References | 1. Liras P. Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus. Appl Microbiol Biotechnol. 2014;98(3):1023-1030. 2. Oliva B, et al. Antimicrobial properties and mode of action of the pyrrothine holomycin. Antimicrob Agents Chemother. 2001;45(2):532-539. 3. Yin H, et al. Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1. Appl Environ Microbiol. 2012;78(9):3431-3441. |