| Description | Hispolon is a polyphenol. Hispolon can be isolated from Phellinus linteus. Hispolon exhibits anticancer, antidiabetic, antiviral, hepatoprotective, antioxidant, and anti-inflammatory activities. |
| In vitro | Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21. Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells.Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells. Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2]. |
| In vivo | Hispolon（5和10 mg/kg，皮下注射）能够减缓DBTRG移植小鼠[3]中的肿瘤生长。Hispolon（2.5-10 mg/kg，腹腔注射）可缓解小鼠[4]中LPS诱导的急性肺损伤。 |
| molecular weight | 220.22 |
| Molecular formula | C12H12O4 |
| CAS | 173933-40-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (510.8 mM), Sonication and heating to 70℃ are recommended. |
| References | 1. Sarfraz A, et al. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017. 2. Arcella A, et al. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. 3. Liao KF, et al. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. 4. Huang CY, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. |