| Description | Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation. |
| In vivo | Hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).?Orally given HMC (3-30 mg/kg, 100 μL) reduced in a dose-dependent manner the MSU-induced hyperalgesia (44%, p |
| molecular weight | 624.59 |
| Molecular formula | C29H36O15 |
| CAS | 24292-52-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (16.1 mM) |
| References | 1. Ruiz-Miyazawa K W , Almeida P R F , Borghi S M , et al. Hesperidin methylchalcone suppresses experimental gout arthritis in mice by inhibiting NF-kB activation[J]. Journal of Agricultural & Food Chemistry, 2018:acs.jafc.8b00959-. 2. Chanal J L , Cousse H , Sicart M T , et al. Absorption and elimination of (14C) hesperidin methylchalcone in the rat[J]. european journal of drug metabolism & pharmacokinetics, 1981, 6(3):171. |