| Description | Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in in vivo experiments. |
| In vitro | Heparin 在给药6天后，表现出对MT-4细胞的HIV细胞病变性的抑制作用，IC50为7.5 μg/mL[2]。在SGHPL-4细胞系中，Heparin 以0.5 U/mL的浓度作用48小时，能够抑制肝细胞生长因子(HGF)诱导的滋养层侵袭[3]。 |
| Target activity | MT-4 cell:7.5 μg/mL |
| Synonyms | Certoparin, Bemiparin, Dalteparin, Adomiparin |
| molecular weight | 1134.9 |
| Molecular formula | C26H42N2O37S5 |
| CAS | 9005-49-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412. 2. Ganapathy R, et al. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod. 2007 Sep;22(9):2523-7. 3. Ito M, et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987 Jul;7(6):361-7. 4. Casu B, Naggi A, Torri G. Re-visiting the structure of heparin. Carbohydr Res. 2015 Feb 11;403:60-8. doi: 10.1016/j.carres.2014.06.023. Epub 2014 Jul 3. Review. PubMed PMID: 25088334. |