| Description | Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes. |
| In vitro | Here we describe the isolation of bufadienolides from the Brazilian toad Rhinella schneideri parotoid glands secretion, including: marinobufagin (1), bufalin (2), telocinobufagin (3), Hellebrigenin (4), and the atypical 20S,21R-epoxymarinobufagin (5) besides the widespread β-sitosterol (6). Starting from natural bufadienolides four derivatives were prepared: 3β-acetoxy-marinobufagin (7), 3β-acetoxy-bufalin (8), 3β-acetoxy-telocinobufagin (9), and 3β-acetoxy-20S,21R-epoxymarinobufagin (10). |
| molecular weight | 416.51 |
| Molecular formula | C24H32O6 |
| CAS | 465-90-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretionToxicon, 2010, 56(3):339-348. |