| Description | Heishuixiecaoline A protects against neurotoxicity in PC12 cells. |
| In vitro | Three new germacrane-type sesquiterpenoids, Heishuixiecaoline A, heishuixiecaoline B, heishuixiecaoline C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. |
| molecular weight | 276.37 |
| Molecular formula | C17H24O3 |
| CAS | 1469493-85-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells.Molecules. 2012 Dec 18;17(12):15013-21. |