| Description | Harringtonine, a natural Cephalotaxus alkaloid, inhibits protein synthesis. |
| In vitro | Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation [1]. Harringtonine displays potent inhibition of Chikungunya virus infection (EC50: 0.24 μM). Harringtonine could inhibit other alphaviruses [2]. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations [3]. |
| Synonyms | 三尖杉酯碱, 三尖杉脂碱 |
| molecular weight | 531.59 |
| Molecular formula | C28H37NO9 |
| CAS | 26833-85-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (103.46 mM) |
| References | 1. Fresno M, et al. Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem. 1977 Jan;72(2):323-30. 2. Kaur P, et al. Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. Antimicrob Agents Chemother. 2013 Jan;57(1):155-67. 3. Piao YF, et al. Growth inhibition of human myeloid leukemia cells in vitro by harringtonine. Gan To Kagaku Ryoho. 1990 Feb;17(2):281-5. |