| Description | Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM) |
| In vivo | In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice.?Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia[1]. |
| Target activity | GABA uptake:10 μM |
| molecular weight | 163.602 |
| Molecular formula | C6H10ClNO2 |
| CAS | 6027-91-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Johnston G A R , Krogsgaard-Larsen P , Stephanson A . Betel nut constituents as inhibitors of γ-aminobutyric acid uptake[J]. Nature. 2. Mantegazza P , Tammiso R , Vicentini L , et al. Nipecotic acid and guvacine antagonism on morphine analgesia in rats[J]. Pharmacol Res Commun, 1979, 11(8):657-662. |