| Description | Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation. |
| In vitro | Grasshopper ketone（100 μg/ml）对RAW 264.7细胞无细胞毒性，能有效抑制LPS诱导的RAW 264.7细胞中NO的产生。[1]同样，grasshopper ketone在0.1-100 μg/ml浓度范围内显著降低了包括IL-6、IL-1β和TNF-α在内的促炎症细胞因子的水平（p<0.05），并证实了其对iNOS和COX-2蛋白表达的剂量依赖性显著抑制作用。[1]此外，grasshopper ketone在0.1、1、10、50以及100 μg/ml的浓度下，显著减少了刺激BALB/c小鼠脾细胞的刀豆素A诱导的IFN-γ和IL-4产生，且无细胞毒性。[3] |
| molecular weight | 224.3 |
| Molecular formula | C13H20O3 |
| CAS | 41703-38-2 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kim MJ, et al. Anti-Inflammatory Effects of Grasshopper Ketone from Sargassum fulvellum Ethanol Extract on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells. J Microbiol Biotechnol. 2019 ; 29(5):820-826. 2. Kato-Noguchi H, et al. Identification of two phytotoxins, blumenol A and grasshopper ketone, in the allelopathic Japanese rice variety Awaakamai. J Plant Physiol. 2012 ; 169(7):682-685. 3. Kang BK, et al. In vivo and in vitro inhibitory activity of an ethanolic extract of Sargassum fulvellum and its component grasshopper ketone on atopic dermatitis. Int Immunopharmacol. 2016 ; 40:176-183. |