| Description | Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9. |
| Target activity | HIV protease:0.006 μg/mL(EC50) |
| Synonyms | 戈米辛G, 戈米辛 G |
| molecular weight | 536.57 |
| Molecular formula | C30H32O9 |
| CAS | 62956-48-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (83.86 mM) H2O: Insoluble |
| References | 1. Chen DF, et al. Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg Med Chem. 1997 Aug;5(8):1715-23. 2. Guo-Jun HE, et al. In silico application in the prediction of herb-drug interaction for cerebrovascular diseases herbs. Lat. Am. J. Pharm., 2016,35 (1): 192-4. |