| Description | Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products |
| In vivo | Glycolic acid(GA) reduced the production of UVB-induced nuclear factor kappa B (NF-κB)-dependent inflammatory mediators [interleukin (IL)-1β, IL-6, IL-8, cyclooxygenase (COX)-2, tumor necrosis factor-α, and monocyte chemoattractant protein (MCP-1)] at both mRNA and protein levels. GA inhibited the UVB-induced promoter activity of NF-κB in HaCaT cells. GA attenuated the elevation of senescence associated with β-galactosidase activity but did not affect the wound migration ability. The topical application of GA inhibited the genes expression of IL-1β, IL-6, IL-8, COX-2, and MCP-1 in UVB-exposed mouse skin. The mice to UVB irradiation after GA was topically applied for 9 consecutive days and reported that 1-1.5% of GA exerted anti-inflammatory effects on mouse skin[1] |
| Animal experiments | The effects of different concentrations of Glycolic acid(GA) on the inflammatory response of human keratinocytes HaCaT cells and C57BL/6J mice dorsal skin.?After GA was topically applied, HaCaT and mice skin were exposed to UVB irradiation[1]. |
| molecular weight | 76.05 |
| Molecular formula | C2H4O3 |
| CAS | 79-14-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (657.46 mM) |
| References | 1. Tang S C , Liao P Y , Hung S J , et al. Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin[J]. Journal of Dermatological Science, 2017:S092318111630915X. |