| Description | Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan inhibits E. coli, S. aureus, and S. enteritidis growths (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL). It enhances membrane permeability and leakage in Glycine max Harosoy 63W cells. |
| In vitro | 疏水修饰的甘露聚糖（Glycol chitosan）已被证实，例如携带5β-胆石酸（5β-cholanic acid）基团和脱氧胆酸-甘露聚糖（deoxycholic acid-Glycol chitosan）的甘露聚糖，能自组装成纳米粒子，作为疏水药物和基因的有希望的载体[2]。甘露聚糖可直接与疏水药物连接生成两亲性化合物，也可形成用于细胞成像和药物输送的纳米粒子（NPs）。甘露聚糖衍生物已成功用于通过物理包裹或化学共轭输送抗微生物剂和抗癌药。使用甘露聚糖衍生物进行细胞成像和药物输送具有多种优势，包括在增强渗透和滞留（EPR）效应基础上的甘露聚糖NPs超强的肿瘤寻家能力，低细胞性毒性，容易化学修饰，极佳的生物相容性和生物可降解性[1]。 |
| Target activity | S. aureus: 32 μg/mL , E. coli:(MIC)4 μg/mL , S. enteritidis:<0.5 μg/mL |
| Synonyms | 羟乙基脱乙酰壳多糖, 乙二醇壳聚糖 |
| molecular weight | N/A |
| CAS | 123938-86-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 7.5 mg/mL, Sonication is recommended. DMSO: 11.67 mg/mL, Sonication is recommended. |
| References | 1. Lin F, et al. Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery. Molecules. 2019 Nov 29;24(23). pii: E4371. 2. Yu A, et al. Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery. Int J Pharm. 2020 Feb 15;575:118943. 3. Young DH, et al. Effect of Chitosan on Membrane Permeability of Suspension-Cultured Glycine max and Phaseolus vulgaris Cells. Plant Physiol. 1982 Nov;70(5):1449-54. 4. Stephen Inbaraj B, et al.Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan.Sci Technol Adv Mater. 2012 Feb 2;13(1):015002. |