| Description | Geranyl acetate is a monoterpene that has been found in C. sativa with diverse biological activities. |
| In vitro | Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action[1].Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells[1]. |
| Cell experiments | The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting.[1]. |
| molecular weight | 196.29 |
| Molecular formula | C12H20O2 |
| CAS | 105-87-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (127.36 mM) |
| References | 1. Qi F , Yan Q , Zheng Z , et al. Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest[J]. Journal of Buon, 2018, 23(2):346-352. 2. Khayyat S A , Sameeh M Y . Bioactive epoxides and hydroperoxides derived from naturally monoterpene geranyl acetate[J]. Saudi Pharmaceutical Journal, 2018, 26(1):14-19. |