| Description | Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity. |
| In vitro | Gentisin的抗增殖效果通过量化VSMC中的DNA合成（BrdU掺入）得到确认。细胞死亡量化（通过培养基中LDH释放确定）显示在所研究的浓度范围内，Gentisin并不具有细胞毒性[1]。 |
| Target activity | VSMC cells:7.84 μM |
| Synonyms | 龙胆根素, 龍膽根素 |
| molecular weight | 258.23 |
| Molecular formula | C14H10O5 |
| CAS | 437-50-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (309.80 mM) |
| References | 1. Waltenberger B, et al. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules. 2015 Nov 13;20(11):20381-90. |