| Description | Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects. |
| In vitro | 经口给予Gardenin A（25 mg/kg）展现了镇静效果，并在不改变入睡时间的情况下增加了睡眠持续时间[2]。 |
| molecular weight | 418.39 |
| Molecular formula | C21H22O9 |
| CAS | 21187-73-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (28.68 mM) |
| References | 1. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63. 2. Alonso-Castro AJ, et al. Evaluation of the neuropharmacological effects of Gardenin A in mice. Drug Dev Res. 2020 Aug;81(5):600-608. |