| Description | Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. |
| In vitro | Garcinol（10-50 μM；24-72小时）诱导HNSCC细胞发生凋亡。Garcinol（50 μM；1-6小时）以时间依赖的方式抑制构成性IκBα的磷酸化和降解。Garcinol（10-50 μM；24-72小时）能够抑制两种测试的HNSCC细胞系（CAL27和UMSCC1）的增殖，其效果随时间和剂量变化。 |
| In vivo | Garcinol显著抑制肿瘤生长。 |
| Target activity | BChE:7.39 µM , AChE:0.66 µM |
| molecular weight | 602.8 |
| Molecular formula | C38H50O6 |
| CAS | 78824-30-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 20 mg/mL (33.18 mM), Sonication and heating are recommended. DMSO: 20 mg/mL (33.18 mM), Sonication and heating are recommended. |
| References | 1. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. 2. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86. 3. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54. |