| Description | Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2/ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax. |
| Synonyms | 7,8-dihydroxy-6-methoxy coumarin, 秦皮素, 弗拉西汀 |
| molecular weight | 208.17 |
| Molecular formula | C10H8O5 |
| CAS | 574-84-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 13 mg/mL (62.45 mM) |
| References | 1. Wang H, et al. Mol Med Rep. 2014 Nov;10(5):2341-5. |