| Description | Filipin complex is a 28-membered cyclopentene macrolide antifungal antibiotic produced by a mixture of S. filipinensis, S. avermitilis, and S. miharaensis that inhibits the entry of PRRSV viruses into cells. |
| In vitro | Filipin complex (2 μg/mL；1+48 小时) 能够抑制 PRRSV 进入，被感染 PRRSV 的 MARC-145 细胞其基因组拷贝减少了 61%[2]。 |
| molecular weight | N/A |
| CAS | 11078-21-0 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 25 mg/mL (38.18 mM), Sonication is recommended. DMSO: 100 mg/mL (152.72 mM) |
| References | 1. Malcolm E. Bergy et al. Filipin complex. Biochemistry, 1968, 7, 2, 653-659. 2. Houdai T, et al. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochim Biophys Acta. 2004 Nov 17;1667(1):91-100. 3. Huang L, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011 Oct 28;414(3):545-50. |