| Description | Febrifugine dihydrochloride (Propyldazine hydrochloride) is a biochemical with therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases. |
| Synonyms | ISF-2123, Propyldazine hydrochloride, Atensil, (+)-Febrifugine dihydrochloride, 常山乙素二盐酸盐, Pildralazine dihydrochloride |
| molecular weight | 374.26 |
| Molecular formula | C16H21Cl2N3O3 |
| CAS | 32434-42-7 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Smullen S, McLaughlin NP, Evans P. Chemical synthesis of febrifugine and analogues. Bioorg Med Chem. 2018 May 15;26(9):2199-2220. doi: 10.1016/j.bmc.2018.04.027. Epub 2018 Apr 12. Review. PubMed PMID: 29681487. 2. Kikuchi H, Horoiwa S, Kasahara R, Hariguchi N, Matsumoto M, Oshima Y. Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial. Eur J Med Chem. 2014 Apr 9;76:10-9. doi: 10.1016/j.ejmech.2014.01.036. Epub 2014 Jan 25. PubMed PMID: 24565569. 3. Jiang S, Zeng Q, Gettayacamin M, Tungtaeng A, Wannaying S, Lim A, Hansukjariya P, Okunji CO, Zhu S, Fang D. Antimalarial activities and therapeutic properties of febrifugine analogs. Antimicrob Agents Chemother. 2005 Mar;49(3):1169-76. PubMed PMID: 15728920; PubMed Central PMCID: PMC549280. |