| Description | Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor. |
| In vitro | 在小鼠中,静脉注射Evodiaminede的LD50为77 mg/kg. |
| In vivo | 在Bcl-2-和 Akt-过表达的U937细胞中,Evodiamine通过胱天蛋白酶非依赖性细胞凋亡途径,诱导细胞凋亡。 |
| Cell experiments | Evodiamine is dissolved in DMSO and diluted with appropriate medium before use. The evodiamine-inspired new scaffolds are assayed for growth inhibitory activities toward human cancer cell-lines A549 (lung cancer), MDA-MB-435 (breast cancer) and HCT116 (colon cancer) using the MTT assay. Evodiamine and camptithecin are used as reference drugs[1]. |
| Synonyms | d-Evodiamine, Isoevodiamine, (+)-Evodiamine, 吴茱萸碱 |
| molecular weight | 303.36 |
| Molecular formula | C19H17N3O |
| CAS | 518-17-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 6.25 mg/mL (20.6 mM) |
| References | 1. Lee TJ, et al. Mol Cancer Ther, 2006, 5(9), 2398-407. 2. Takada Y, et al. J Biol Chem, 2005, 280(17), 17203-17212. 3. Dong G, et al. J Med Chem, 2010, 53(21), 7521-31. 4. Yang XW, et al. J Asian Nat Prod Res, 2006, 8(8), 697-703. 6. Li RF,et al. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine inRats. Pharmacology. 2016;97(1-2):43-7. 7. Shi L, et al. Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis. Tumour Biol. 2016 Sep;37(9):12791-12803. |