| Description | Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.SB-674042 is used for the treatment of depression.SB-674042 is used for the treatment of depression.SB-674043 is used for the treatment of depression.SB-674044 is used for the treatment of depression.SB-674045 is used for the treatment of depression. 2A (BU-1) cell differentiation. |
| In vitro | Euxanthone(10-20 μM；24 h)抑制了骨肉瘤细胞的细胞粘附、迁移和侵袭，并且 Euxanthone 抑制COX-2介导的抗转移活性。Euxanthone 也通过miR-21/PDCD4/c-jun信号通路调节COX-2的表达[1]。 |
| In vivo | BCCAO 引起线粒体氧化应激并导致线粒体分解,而 Euxanthone 给药显着减弱 BCCAO 引发的线粒体应激和相关分解。而 Euxanthone 治疗(30-60 mg/kg；口服；每天一次；持续 7 天)能使 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化[2]。 |
| Synonyms | 1,7-Dihydroxyxanthone |
| molecular weight | 228.2 |
| Molecular formula | C13H8O4 |
| CAS | 529-61-3 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. 2. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. 3. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. |