| Description | Ethyl glucoside (β-D-Glucopyranoside, ethyl), a shale inhibitor for water-based drilling fluids, is a versatile initiator of enzyme-catalyzed regioselective lactone ring-opening polymerization and is a natural compound found in Sisyrinchium palmifolium. |
| In vitro | EG存在为α（alpha）和β（beta）异构体。本研究中，发现0.48 μM的α-EG能够使正常人类真皮成纤维细胞（NHDF）的增殖率提高121.0%，在0.048 μM的α-EG浓度下，NHDF产生的I型胶原量增加了159.6%，与未添加α-EG的细胞培养相比。在添加α-EG的培养基中培养的NHDF，I型和VII型成纤维细胞生长因子（fibroblast growth factor I and VII）mRNA的表达，在4.8和0.048 μM的α-EG浓度下分别增加了148.8%和153.1%，该结果通过定量逆转录聚合酶链反应（quantitative reverse transcription-polymerase chain reaction）测量。I型胶原基因COL1A1和COL1A2的转录水平分别增加了152.4%和129.7%，III型胶原基因COL3A1在0.48 μM的α-EG浓度下增加了131.8%。[3][4] |
| In vivo | 使用1H NMR 谱学对人类尿样进行代谢组学筛选，发现了由Ethyl glucoside排泄产生的信号。志愿者实验表明，该Ethyl glucoside来源于饮食摄入的该化合物，存在于如米酒和清酒等饮料中，而不是代表人类乙醇代谢的新途径。在志愿者中进行的有限研究表明，Ethyl glucoside的生物半衰期比乙醇本身要长。考虑到将这种葡萄糖苷代谢物作为饮酒标志的潜在问题。[2] |
| Synonyms | β-D-Glucopyranoside, ethyl, Ethyl D-glucoside |
| molecular weight | 208.21 |
| Molecular formula | C8H16O6 |
| CAS | 3198-49-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (288.17 mM) |
| References | 1. Bisht K S , et al. Ethyl Glucoside as a Multifunctional Initiator for Enzyme-Catalyzed Regioselective Lactone Ring-Opening Polymerization. Journal of the American Chemical Society, 1998;120(7):1363-1367. 2. Teague C , et al. Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans. Analyst, 2004;129(3):259. 3. Waters B, et al. A validated method for the separation of ethyl glucoside isomers by gas chromatography-tandem mass spectrometry and quantitation in human whole blood and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2022;1188:123074. 4. Bogaki T, et al. Effects of ethyl-α-d-glucoside on human dermal fibroblasts. Biosci Biotechnol Biochem. 2017;81(9):1706-1711. |