| Description | Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB and inhibits hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock. Also, Ethyl gallate suppresses proliferation and invasion in human breast cancer cells by modulating the PI3K/Akt pathway, which may contribute to inhibiting their downstream targets such as NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9 in breast cancer cells, could be used as potential antioxidants with safe therapeutic application in cancer chemotherapy. |
| Synonyms | Nipagallin A, Phyllemblin, gallic acid ethyl ester, 没食子酸乙酯 |
| molecular weight | 198.17 |
| Molecular formula | C9H10O5 |
| CAS | 831-61-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 36 mg/mL(181.7 mM) |
| References | 1. Cui H, et al. Oncol Rep. Ethyl gallate suppresses proliferation and invasion in human breast cancer cells via Akt-NF-κB signaling. 2015 Mar;33(3):1284-90. 2. Mohan S, et al. Nat Prod Res. 2015;29(4):366-9. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. |