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Erythromycin estolate

CAS No.: 3521-62-8

Erythromycin estolate is a derivative of erythromycin, which belongs to the macrolide class of antibiotics and is often
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Description Erythromycin estolate is a derivative of erythromycin, which belongs to the macrolide class of antibiotics and is often used to study a variety of bacterial infections. Erythromycin estolate has an inhibitory effect on bile acid transport and may cause liver injury, mainly cholestatic hepatitis.
In vitro Erythromycin estolate在不同细胞类型中有效抑制了HCoV-OC43感染,并在安全浓度下显著降低了病毒滴度。此外,研究发现erythromycin estolate能够在早期阶段抑制HCoV-OC43感染,并通过破坏病毒膜的完整性以不可逆的方式灭活病毒,其作用目标可能是病毒膜的脂质成分。综上所述,erythromycin estolate有望成为治疗HCoV-OC43感染的潜在药物。[1]
Synonyms Phtalic anhydride, ilosone
molecular weight 1056.39
Molecular formula C52H97NO18S
CAS 3521-62-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility DMSO: 45 mg/mL (42.6 mM), Sonication is recommended.
References 1. Wang X, et al. Erythromycin Estolate Is a Potent Inhibitor Against HCoV-OC43 by Directly Inactivating the Virus Particle. Front Cell Infect Microbiol. 2022;12:905248. 2. Charoensareerat T,et al. Efficacy and Safety of Enteral Erythromycin Estolate in Combination With Intravenous Metoclopramide vs Intravenous Metoclopramide Monotherapy in Mechanically Ventilated Patients With Enteral Feeding Intolerance: A Randomized, Double-Blind, Controlled Pilot Study. JPEN J Parenter Enteral Nutr. 2021;45(6):1309-1318. 3. Lu X, et al. Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat. Food Chem Toxicol. 2014;65:343-55.