| Description | Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.Ermanin has anti-inflammatory activity by inhibiting the expression of iNOS and COX-2.Ermanin may have anti-HIV-1 activity. Ermanin is effective in inhibiting Dione juno larvae at lower concentrations. |
| In vitro | Ermanin (3.25, 6.25, 12.5, and 25 μM) on modulation of LPS-induced iNOS and COX-2 expression in RAW 264.7 cells. Ermanin decreased LPS-induced COX-2 and iNOS expression by 94 ± 0.5% and 94 ± 0.5% with IC50 were 1.68 μM and 6.70 μM, respectively.[1] |
| Synonyms | 堪非醇3,4'-二-O-甲醚 |
| molecular weight | 314.29 |
| Molecular formula | C17H14O6 |
| CAS | 20869-95-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Guerra JA, et al. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum. Int Immunopharmacol. 2006;6(11):1723-1728. 2. Appunni S, et al. Targeting PknB, an eukaryotic-like serine/threonine protein kinase of Mycobacterium tuberculosis with phytomolecules. Comput Biol Chem. 2017;67:200-204. 3. Chen JJ, et al. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria. Molecules. 2016;21(10):1385. |