| Description | Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. |
| In vitro | Epoxyazadiradione 在 TNBC 和 ER+ 乳腺癌细胞中显示出最强的抗癌活性。它诱导凋亡并抑制 PI3K/Akt 介导的线粒体潜能、细胞活力、迁移和血管生成。此外，还抑制这些细胞中如 Cox2、OPN、VEGF 和 MMP-9 等促血管生成和促转移基因的表达。进一步地，Epoxyazadiradione 降低了 PI3K/Akt 介导的 AP-1 激活。Epoxyazadiradione 在正位 NOD/SCID 小鼠模型中抑制乳腺肿瘤生长和血管生成。 |
| molecular weight | 466.57 |
| Molecular formula | C28H34O6 |
| CAS | 18385-59-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (128.6 mM) |
| References | 1. Kumar D , Haldar S , Gorain M , et al. Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway[J]. Bmc Cancer, 2018, 18(1). |