| Description | Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis. |
| In vitro | Emodin-6-O-β-D-葡萄糖苷（EG）是从Reynoutria japonica中提取的一种新活性化合物。研究发现，EG能够抑制高迁移率族蛋白B1（HMGB1）的释放、肿瘤坏死因子（TNF）-α的产生，以及HMGB1在人脐静脉内皮细胞（HUVECs）中诱发的核因子κB（NF-κB）的激活。 |
| In vivo | Emodin-6-O-β-D-glucoside（EG）亦能抑制HMGB1介导的小鼠高渗透性及白细胞迁移。此外，EG还能延长经CLP处理的小鼠的生存时间。 |
| Synonyms | 大黄素-6-O-β-D-葡萄糖苷, Glucoemodin |
| molecular weight | 432.38 |
| Molecular formula | C21H20O10 |
| CAS | 34298-85-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/ml (150.33 mM) |