| Description | Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. |
| In vitro | Dryocrassin ABBA and its analogues (b5 and e2) showed better NAs inhibitory activity against Anhui H7N9 with IC values of 3.6 μM, 2.5 μM and 1.6 μM.?For the highly resistant Shanghai N9, these compounds can also show medium inhibitory activities.?Docking results indicated the direct interaction of synthesized 3 hits with the key K294 by hydrogen bonds, but no direct interaction of OSV with the key K294 was observed in Shanghai N9.?dryocrassin ABBA and its analogues especially AB, which consisted of polyphenol groups may have beneficial effects on treating avian influenza H7N9 virus[2]. |
| Synonyms | 东北贯众素, Dryocrassin |
| molecular weight | 820.83 |
| Molecular formula | C43H48O16 |
| CAS | 12777-70-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Dryocrassin ABBA Induces Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells Through a Caspase-Dependent Mitochondrial Pathway. Asian Pac J Cancer Prev. 2016;17(4):1823-8. 2. Hou B , Liu Z , Yang X B , et al. Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases[J]. Bioorganic & Medicinal Chemistry, 2019, 27(17):3846-3852. |