| Description | Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils. |
| In vitro | Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 μM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 μM[1].?Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet[2].?Formulations containing docosanoic acid have been used in hair conditioner and moisturizers. |
| Synonyms | Behenic Acid, 山嵛酸 |
| molecular weight | 340.58 |
| Molecular formula | C22H44O2 |
| CAS | 112-85-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 1 mg/mL (2.9 mM), Sonication and heating to 50℃ are recommended. |
| References | 1. Yonezawa Y , Hada T , Uryu K , et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases[J]. International Journal of Molecular Medicine, 2006, 18(4):583---588. 2. Serviddio G , Bellanti F , Villani R , et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach[J]. Redox Biology, 2016, 9:296-305. |