| Description | Docosahexaenoic Acid is a naturally occurring omega-3 fatty acid that is found in abundance in the brain and retina. Docosahexaenoic Acid is essential for the growth and functional development of the brain. |
| In vitro | 方法：牛颗粒细胞用 Docosahexaenoic Acid (1-50 µM) 处理 24 h，使用 3H-thymidine 检测细胞增殖。结果：Docosahexaenoic Acid 在 10 µM 和 50 µM 时显著增加基础细胞增殖。[1]方法：人卵巢癌细胞系 A2780、HO8910 和 SKOV-3 用 Docosahexaenoic Acid (32-1024 µM) 处理 72 h，使用 CCK-8 assay 检测细胞活力。结果：在用 Docosahexaenoic Acid 治疗后，A2780、HO8910 或 SKOV-3 细胞中观察到显著的抑制作用，且呈剂量依赖性。[2] |
| In vivo | 方法：为研究对帕金森病 (PD) 实验小鼠模型中发生的氧化应激的影响，将 Docosahexaenoic Acid (36 mg/kg) 灌胃给药给 MPTP 诱导 PD 的小鼠，每天一次，持续四周。结果：与 MPTP 组相比，Docosahexaenoic Acid 酸显著降低了联合组的细胞死亡量。与对照组相比，MPTP 处理组的脑超氧化物歧化酶 (SOD) 活性降低，但 Docosahexaenoic Acid 处理对 SOD 活性没有影响。数据表明，Docosahexaenoic Acid 治疗对实验性帕金森病小鼠模型具有神经保护作用。[3] |
| Synonyms | Cervonic acid, DHA |
| molecular weight | 328.49 |
| Molecular formula | C22H32O2 |
| CAS | 6217-54-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (304.42 mM), Sonication is recommended. H2O: 5 mg/mL (15.22 mM) |
| References | 1. Maillard V, et al. Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells. Reprod Biol Endocrinol. 2018 Apr 26;16(1):40. 2. Wang YC, et al. Docosahexaenoic Acid Modulates Invasion and Metastasis of Human Ovarian Cancer via Multiple Molecular Pathways. Int J Gynecol Cancer. 2016 Jul;26(6):994-1003. 3. Ozsoy O, et al. The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. Neurochem Int. 2011 Oct;59(5):664-70. |