| Description | DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment. |
| In vitro | Tryptophan是一种必需氨基酸，对于血清素的生产至关重要。由于其作为神经递质血清素生产的前体的角色，Tryptophan对大脑功能具有关键意义[2]。 |
| In vivo | 在临床条件下，如持续性免疫系统激活或接受细胞因子治疗时，由于Tryptophan的高分解代谢，常见Tryptophan水平降低，这可以通过犬尿氨酸与Tryptophan比率的指标来表明，这种情况常与抑郁情绪相关[2]。 |
| Synonyms | (±)-Tryptophan, Tryptophan, DL-色氨酸 |
| molecular weight | 204.23 |
| Molecular formula | C11H12N2O2 |
| CAS | 54-12-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mg/mL (24.48 mM), Sonication and heating to 60℃ are recommended. H2O: Insoluble |
| References | 1. Di Pizio A, Nicoli A. In Silico Molecular Study of Tryptophan Bitterness. Molecules. 2020 Oct 11;25(20):4623. 2. Strasser B, Gostner JM, Fuchs D. Mood, food, and cognition: role of tryptophan and serotonin. Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):55-61. |