| Description | Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema. |
| Synonyms | 二羟丙茶碱, Dyphylline, Diprophylline |
| molecular weight | 254.24 |
| Molecular formula | C10H14N4O4 |
| CAS | 479-18-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (216.33 mM) H2O: 47 mg/mL (184.9 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Schwabe U, et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21. |