| Description | Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling. |
| In vitro | 大鼠腹腔注射1 mg/kg Dihydromyricetin中和急性酒精中毒,并且使耐受性,增加的焦虑,惊厥易感的迹象消失. LD50: 腹腔注射小鼠1.41 g/kg. |
| In vivo | Dihydromyricetin（1 μM）作为一种新型的抗酒精中毒药物拮抗急性乙醇诱导的GABA（A）Rs和EtOH暴露/撤退诱导的GABA（A）R可塑性增强和GABA（A）R α4亚基在海马和培养的神经元中的表达。Dihydromyricetin有效清除DPPH,还抑制亚油酸系统中FeSO4乙二胺四乙酸催化的脂质过氧化值的增加。 |
| Target activity | mTOR:48 μM |
| Synonyms | Ampelopsin, Ampeloptin, 二氢杨梅素 |
| molecular weight | 320.25 |
| Molecular formula | C15H12O8 |
| CAS | 27200-12-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 60 mg/mL (187.4 mM) DMSO: 60 mg/mL (187.4 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Zhang YS, et al. Yao Xue Xue Bao, 2003, 38(4), 241-244. 2. Shen Y, et al. J Neurosci, 2012, 32(1), 390-401. 3. Liu H, Ye F, Sun Q, et al. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro[J] . Medicinal Chemistry. 2021, 36(1): 497-503. |