| Description | Dihydroartemisinin (Artenimol) is a metabolite of artemisinin. |
| In vitro | Dihydroartemisinin (DHA)抑制某些癌细胞系和异种移植瘤的生长，其中包括白血病、胶质瘤、纤维肉瘤、乳腺癌、宫颈癌、卵巢癌、肺癌、口腔癌和胰腺癌。DHA通过调节促增殖和促凋亡相关蛋白来调控不同的抑瘤途径，抑制细胞增殖，诱导凋亡。DHA以剂量依赖的方式抑制细胞增殖和活力，并诱导凋亡。DHA介导的细胞毒性具有肿瘤选择性。DHA的内过氧桥被认为是其细胞毒性的关键，因为它能与细胞内的亚铁离子反应，产生活性氧种或碳中心自由基，导致细胞毒性[1]。 |
| In vivo | DHA通过诱导G2/M期细胞周期阻滞和凋亡作用来抑制了HCC细胞在体外和体内的生长。在大鼠全胚胎培养(WEC)中，DHA主要影响原始红细胞(RBCs)促进组织损伤和畸形发育[3]。 |
| Cell experiments | BxPc3-RFP cells (3.5×104cells/well) were seeded in poly D-lysine-coated black, μClear 96-well plates with 0.2 ml medium. After 24 h, the cells were treated with dimethyl sulfoxide (DMSO) (control) or different concentrations (2.5, 10, 40, or 80 μM) of DHA dissolved in DMSO for 24, 48, and 72 h. At each time point, the fluorescence intensity emitted from cells was measured. (Only for Reference) |
| Synonyms | 双氢青蒿素, β-Dihydroartemisinin, Dihydroqinghaosu, Artenimol, DHA |
| molecular weight | 284.35 |
| Molecular formula | C15H24O5 |
| CAS | 71939-50-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 9 mg/mL (31.7 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 52 mg/mL (182.9 mM) |
| References | 1. Aung W, et al. Anticancer Res. 2011, 31(5):1549-1558. 2. Zhang CZ, et al. Biochem Pharmacol. 2012, 83(9):1278-1289. 3. Longo M, et al. Reprod Toxicol. 2006, 22(4):797-810. |